Upregulation of miR-133b and miR-328 in Patients With Atrial Dilatation: Implications for Stretch-Induced Atrial Fibrillation

The role of gap junctions in stretch-induced atrial fibrillation

AIMS The aim of this study was to investigate the role of gap junctions in atrial fibrillation (AF) by analysing the effects of a gap junction enhancer and blocker on AF vulnerability and electrophysiological properties of isolated hearts. METHODS AND RESULTS The acute atrial stretch model of AF in the isolated rabbit heart was used. Sustained AF (SAF) was induced by a burst of high-frequency...

radiofrequency atrial fibrillation ablation technique in patients with mitral valve surgery and left atrial reduction procedures

background: about half of all patients who undergo mitral valve surgery suffer from atrial fibrillation (af). cox described the surgical cut-and-sew maze procedure, which is an effective surgical method but has some complications. this study was designed to evaluate the efficacy of a substitution method of radiofrequency ablation (rfa) for patients undergoing mitral valve surgery with af. metho...

clinical implications of recent trials on anticoagulation in patients with atrial fibrillation

Atrial Fibrillation Atrial Fibrillation Pathophysiology Implications for Management

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important contributor to population morbidity and mortality. An arrhythmia that is particularly common in the elderly, AF is growing in prevalence with the aging of the population. Our understanding of the basic mechanisms that govern AF occurrence and persistence has been increasing rapidly. This article reviews the ...

miR-1 and miR-133b Are Differentially Expressed in Patients with Recurrent Prostate Cancer

Prostate cancer (PCa) is currently the most frequently diagnosed malignancy in the western countries. It is more prevalent in older men with 75% of the incident cases above 65 years old. After radical prostatectomy, approximately 30% of men develop clinical recurrence with elevated serum prostate-specific antigen levels. Therefore, it is important to unravel the molecular mechanisms underlying ...